Dr. George Engelmann, a physician and the Academy's first president and a prominent amateur botanist, helped plan the renowned Missouri Botanical Garden.
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It was founded in 1856 by a group of scientists and businessmen in St. Louis, including George Engelmann and James B. Eads, the Academy has been involved in many science-related activities in the city.
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After military participation in Texas, Lindheimer moved to St. Louis, Missouri to partner in botanical research with George Engelmann and Asa Gray.