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It remained the formal head of the army, although in fact it was bestowed to generals and high-ranking courtiers alike, among others George Mouzalon, John Palaiologos (brother of Michael VIII), Michael Tarchaneiotes, Alexios Strategopoulos and John Kantakouzenos (the future John VI).
In the midst of this crisis, Theodore II's epileptic condition worsened, and the Emperor died on August 18, 1258, leaving George Mouzalon as the regent for his minor son John IV Laskaris.