Early in her career, Gisselle was featured in several comedy sketches in programs like El Show de las 12 and No te Duermas.
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In 2007, Gisselle was invited to host the morning radio show El Bayú de la Mañana at SalSoul.
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She participated as a dancer in several shows in venues like the Luis A. Ferré Performing Arts Center.
The Pillow Head Hour was a one-hour block of E/I-compliant programming on the now-defunct Kids WB, featuring two half-hour series and framed by interstitial segments hosted by Pillow Head reporter Gisselle.