Produced by Jermaine Dupri and Manuel Seal, Jr., who used a sample of the Mary Jane Girls' "All Night Long", "Give It 2 You" was the final single from Da Brat's platinum-certified album Funkdafied after "Funkdafied" (#6 US) and "Fa All Y'all" (#37 US).
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The song's promotional music video featured appearances from Jermaine Dupri, MC Lyte, The Notorious B.I.G., Sean "Puffy" Combs, Keith Murray, Too Short, T-Boz and Bill Bellamy, among others.
The song also reached No. 85 on the Billboard Year-End Hot 100 singles of 2000, becoming her third song to reach the Year-End charts after "Funkdafied" in 1994 and "Give It 2 You" in 1995.
Something's Gotta Give | Give Peace a Chance | Something's Gotta Give (film) | Something's Got to Give | Give Us a Clue | You Get What You Give | I Can't Give You Anything but Love, Baby | Give My Regards to Davy | Give My Regards to Broadway | Give Me All Your Luvin' | Give It Up or Turnit a Loose | Give It 2 Me | Never Gonna Give You Up | Never Give Up: The 20th Century Odyssey of Herbert Zipper | I Give It a Year | I Can't Give You Anything But Love | Give Us This Day | Give Up the Ghost | Give Me Convenience or Give Me Death | Frankly, my dear, I don't give a damn | Don't Give Up Your Day Job Productions | Something's Gotta Give (movie) | Something's Gotta Give (LeAnn Rimes song) | Never, Never Gonna Give Ya Up | Love Isn't Love ('Til You Give It Away) | John and Yoko in 1969 recording ''Give Peace a Chance | I Won't Give Up on You | If I Give My Heart to You | Got to Give It Up | Give Yourself Goosebumps |