Governor Sir Elihu Yale (the initial benefactor of the world-renowned Yale University) was instrumental in the development of the Hospital and gave it new premises within the Fort in 1690.
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His conglomerate built several landmarks, businesses and institutions in coastal Tamil Nadu viz. Chennai Citi Centre, Chepauk Stadium, Anna Nagar Tower, Marina Lighthouse, Valluvar Kottam, Government General Hospital, Gemini Flyover, Raheja Towers, Star Health and Allied Insurance, Crescent Engineering College, etc..