The Grande Ronde River flows through the valley; its tributaries include Catherine, Fir, Ladd, Little, Mill, Pyles, and Willow creeks.
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In 1878, several La Grande residents spearheaded an effort to build a railroad from La Grande to the Columbia River at Umatilla.
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Medical Springs Highway (Oregon Route 203): This highway leaves the valley through the canyon of Catherine Creek.
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Mormons were attracted to the valley after an 1889 business trip by David Eccles, Charles W. Nibley, and George Stoddard, who set up businesses in the area.
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