Eno asked Frith to record with him, and this resulted in Frith playing guitar on two of Eno's albums, Before and After Science (1977) and Music for Films (1978).
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Using volume pedals on some of the sound sources, he filtered sounds in and out of the mix without doing anything on the guitars.
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Where the original studio version clocked in at only 3:57, live performances include a bass solo in addition to the song's piano and guitar solos, and an extended interlude where lead vocalist Kevin Cronin tells a story that leads up to a "conversation" between him and lead guitarist Gary Richrath (later Dave Amato) where the guitarist's side consists of guitar solos while Kevin's side is scat vocals.
The song was covered by British Death Metal band The Rotted on their album Get Dead Or Die Trying, and indie developer James Silva for the Xbox Live Arcade game The Dishwasher: Vampire Smile, in a Guitar Hero style mini-game segment where the protagonists play guitar solos.
During 1999–2000, Doyle Bramhall II and Snowy White stood in for Gilmour's vocals and guitar solos; a role carried out by Chester Kamen and White in 2002.
The song was popular on the Dr. Demento Show in the 70s, and in Zappa's concerts, with memorable guitar solos from Zappa, also featuring George Duke on keyboard and Napoleon Murphy Brock on sax.
Mick Ronson contributed one of the three guitar solos on "My Baby is a Headfuck."
The song appeared in instrumental form (the middle keyboard and guitar solos) as part of the 1992 We Can't Dance tour and 1998 Calling All Stations tour, as well as in 2007's Turn It On Again: The Tour.
The Pirates, when they established themselves in 1962-64 and again from 1976 onwards as a separate, power trio entity from Johnny Kidd & the Pirates, were pioneers of the technique of playing guitar solos with a thick chordal rhythm-guitar-like style, which was later popularised by Wilko Johnson of Dr. Feelgood in the 1970s.
During the band's performance of "Rocket Queen", the 15th song in the set (counting drum & guitar solos), lead singer Axl Rose, in the middle of the chorus, pointed out a fan who was taking still pictures of the show, saying "...Hey, take that! Take that! Now, get that guy and take that!"
A "blip"-like sound comparable to the sounds later made by Pac-man and the Nintendo Entertainment System pulses throughout the song, which, coupled with extremely rhythmic guitar solos, creates a frantic pace.