His loss of the Izu Province to Hōjō Sōun in 1492–1498 marked a significant development of Japan's Sengoku period.
Hōjō clan | Late Hōjō clan | Hōjō, Fukuoka | Hōjō clan's | Hōjō | Hōjō Takatoki | Tsukasa Hojo | Hōjō Tokiyuki | Hōjō Sōun | HoJo | Hojo | Hideji Hōjō |
Nagao Tamekage, rose up against him in 1510 with the help of Hōjō Sōun, seizing the province and killing Akisada.