Treatment with melatonin in old mice with age related liver inflammation decreased the mRNA expression of TNF-α, IL-1β, HO (HO-1 and HO-2), iNOS, CCL2, NF-κB1, NF-κB2 and NKAP in old male mice.
Heme oxygenase 2 (HO-2) is a constitutive isoform that is expressed under homeostatic conditions.
HMOX2 |