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The freaks in the Freakshow at the "Psychedelic Circus" were all based on the styles of "Big Daddy" Ed Roth and Harvey Kurtzman, both of whom were good friends of Simon.
At EC Comics during the early 1950s, DeFuccio was an assistant editor and researcher on Harvey Kurtzman's war comics, Frontline Combat and Two-Fisted Tales, research that on one day involved taking a trip underwater in a submarine.
In Please Kill Me: The Uncensored Oral History of Punk, McNeil said that the magazine was inspired by two chief influences: cartoonist and editor Harvey Kurtzman, and The Dictators' debut album The Dictators Go Girl Crazy!, indicating that the magazine was started strictly so that its creators could "hang out with the Dictators".
Pieces were created especially for the book by writers, artists, and composers including the writer William Burroughs, the filmmaker Federico Fellini, the writer Tom Wolfe, the musician Frank Zappa, the cartoonist Harvey Kurtzman, the cartoonist Gahan Wilson, the artist Red Grooms, and 160 others.
In 1993, Dark Horse Comics published two issues of Harvey Kurtzman's The New Two-Fisted Tales, featuring war stories by contemporary creators.