At the age of seventeen she married Sir Henry Cary (sometimes Carey), later Viscount Falkland, and over the next decades she bore eleven children, including Lucius Cary, 2nd Viscount Falkland, and Patrick Cary.
O'Byrne however was undeterred, addressing a flood of petitions to the English Crown, accusing Esmonde and the Lord Deputy of Ireland, Lord Falkland, of conspiracy and perjury.
Among some of the other prominent members of the London and Bristol Company, Henry Cary, 1st Viscount Falkland became a supporter of the venture.
When Henry Cary, 1st Viscount Falkland was appointed Lord Deputy of Ireland, Delaune accompanied him as his physician, and resided for some years in Dublin.
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Falkland believed that his difficulties with the nobility had been largely due to the intrigues of the Lord Chancellor of Ireland, Adam, Lord Loftus, After the dissolution of the assembly of the nobility in 1627, he brought a charge against Loftus of malversation, and of giving encouragement to the nobility to refuse supplies.
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Henry Cary, 1st Viscount Falkland PC (c. 1575 – September 1633) was an English landowner and politician who sat in the House of Commons from 1601 to 1622.