Chester E. Holifield (1903–1995), United States Representative from California
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John Holifield (born 1964), American football running back for the West Virginia Mountaineers
The Chet Holifield Federal Building, colloquially known as "the Ziggurat Building", is a United States government building at 24000 Avila Road in Laguna Niguel, California built between 1968 and 1971, originally for Rockwell International, and designed by William Pereira.