A third member of this family - RHBDD1 - cleaves Bcl-2-interacting killer (BIK) - a proapoptotic member of the B cell lymphoma 2 (Bcl-2) family.
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A second related gene - rhomboid family 1 (RHBDF1) - appears to be important in head and neck cancer.
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The name is intimately linked with the Kynaston family, the first to carry the surname being Gruffydd Kynaston of Cae Howel, a settlement in the locality.
Geoffrey's Cligueillus / Digueillus may be a corruption of the Old Welsh name Higuel (specifically, the 10th century AD king Higuel (Howel/Houuel) Bonus - i.e. Hywel Dda - mentioned in one of Geoffrey's sources, the Annales Cambriae, now Modern Welsh Howell.