John M. Hyneman (1771–1816), a Pennsylvanian member of the U.S. House of Representatives from March 4, 1811
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Jamie Hyneman (born 1956), an American special effects expert, best known for being the co-host of the television series MythBusters
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Frank Hyneman Knight (1885–1972), an important economist in the first half of the 20th century
Starting with the second season, members of Hyneman's staff were introduced and began to appear regularly in episodes; Kari Byron, Tory Belleci and welder Scottie Chapman appeared in the second season.
Hyneman was elected as a Republican to the Twelfth and Thirteenth Congresses and served until his resignation on August 2, 1813.
Grant Imahara also explained that he asked Jamie Hyneman what the "M" stood for in M5 to which he replied "Movies, Monsters, Mechanics, Machining..." and Grant was thinking that the final M comically stood for Mustache.