The onset of symptoms is usually sudden with high fever, severe headache, pain on moving the eyeballs, soreness of the muscles of the legs and back, and frequently hyperaesthesia of the shins.
The first description of symptoms associated with alcoholic polyneuropathy were recorded by John C. Lettsome in 1787 when he noted hyperesthesia and paralysis in legs more than arms of patients.
Dieulafoy's triad: hyperesthesia of the skin, exquisite tenderness and guarding over McBurney's point, considered a classic sign of acute appendicitis