Aka II is one of the daughters born to the King of Commagene, Mithridates III who reigned from 20 BC until 12 BC from his cousin-wife Queen Iotapa, thus was a sister of Antiochus III of Commagene.
Iotapa left Egypt to return to her father and later married her maternal cousin King Mithridates III of Commagene, who was of Armenian and Greek descent.
Epiphanes was the first-born son and child to King Antiochus IV of Commagene and Queen Iotapa of Commagene.