Biological Procedures Online was founded in 1997 by Mark Reimer, a surgeon at the University of Waterloo, Canada, and Irem Ali, now Director of Operations for Biological Procedures.
Hammerin' Harry can be seen on the arcade flyers of Ninja Baseball Bat Man, also by Irem.
In Japan, these companies manufactured the game cartridges for the Famicom: Nintendo, Konami, Capcom, Namco, Bandai, Taito, Irem, Jaleco, Sunsoft and Hudson Soft.
An issue of Famitsu revealed details that the title moved production to the PlayStation 3 and that Irem would unveil a new trailer at the 2007 Tokyo Game Show.
The Directive came to prominence during the 2009 Lindsey Oil Refinery strikes after British workers at the Lindsey Oil Refinery in North Killingholme, North Lincolnshire claimed that they were being undercut by skilled foreign labour when the Italian construction contractor IREM appointed several hundred European (mainly Italian and Portuguese) contractors on the site at a time of high unemployment in the local and global economy.
In the PlayStation 3's community-based social gaming network, PlayStation Home, Irem has released a Game Space in the Japanese Home on December 3, 2009 to promote the release of R-Type Tactics II: Operation Bitter Chocolate on the PSP and PSPgo.