The couple had two children, Alessandro (1520–1580), who became State Councillor of the Duchy of Mantua and served in the Spanish army in Flanders during the Dutch Revolt, and Emilia (1517–1573) who married Carlo Gonzaga (1523–1555) signore di Gazzuolo, with whom she had ten children.
Several attempts have been made to identify the main female figure – these have included Titian's lover, Alfonso d'Este's lover Laura Dianti, or Federico Gonzaga's lover Isabella Boschetti.
Isabella I of Castile | Isabella | Isabella II of Spain | Tony Isabella | Isabella Stewart Gardner | Isabella Rossellini | Isabella Boschetti | Order of Isabella the Catholic | Isabella of Portugal | Isabella of France | Isabella Greenway | Isabella d'Este | Isabella Calthorpe | Isabella Thoburn College | Isabella Castillo | The marriage contract was annulled, however, after Federico accused Maria of attempting to poison his mistress Isabella Boschetti, wife of the Count of Calvisano.Margaret Paleologa
see also