This case is potentially physically interesting in the case that the shape of the universe is a multiply connected 3-manifold, since finding the angles of the eigenrotations of a candidate isometry for topological lensing is a way to falsify such hypotheses.
As with the hypercube graphs, and their isometric (distance-preserving) subgraphs the partial cubes, a halved cube graph may be embedded isometrically into a real vector space with the Manhattan metric (L1 distance function).