An Isotta also makes a featured appearance in the 1946 film Without Reservations with John Wayne and Claudette Colbert.
Although the Italian public expressed a great deal of concern that the Asso 1000 engine was not ready for Schneider Trophy competition—Isotta-Fraschini built 27 of them for the 1929 Schneider Trophy race, but some exploded during testing—the Italian Air Minister, Italo Balbo (1896–1940), believed that the M.67 had the best chance of winning the race and selected it to represent Italy.