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However, by the time of Nakatomi no Kamatari, in the early 7th century, the clan had switched sides, possibly as a result of their loyalty and close connection to the Imperial family; following Prince Shōtoku, likely the most famous advocate of Buddhism in all of Japanese history, and later Prince Naka no Ōe, the Nakatomi helped eliminate the Soga clan, powerful and very active supporters of Buddhism, and of the current administration of the time (see Isshi Incident).