Cruizer was attached to Sir Hyde Parker's Baltic fleet on commissioning and Brisbane came under the direct command of Admiral Horatio Nelson, who used Cruizer to take soundings and make charts of the approaches to Copenhagen prior to the British attack on the city at the Battle of Copenhagen.
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Although never engaged in any major actions, Brisbane served under both Lord Howe and Horatio Nelson and performed important work at the Cape of Good Hope, prior to the Battle of Copenhagen and in the Adriatic campaign of 1807–1814.
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During the campaign however he contracted a fatal illness and died from it at Penang in Malaya late in 1826.
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