These two studies led on to one of the first ever longitudinal birth cohort studies, the Newcastle Thousand Families Study, although with the outbreak of the second world war, it was not until 1947 that the members of this cohort could be recruited.
The initial thoughts leading to the development of the Thousand Families Study arose through observations made by Sir James Spence, one of the first ever full time paediatricians in the United Kingdom, and from 1942, the first holder of a University Chair of Child Health in England.
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