Her first husband was Sir Walter Mantell (d.1529) of Nether Heyford, Northamptonshire, by whom she had three sons, John, Walter and Thomas, and at least two daughters, Margaret and Anne.
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After the death of Sir James Hales (d.1589), Alice married Sir Richard Lee (d. 22 December 1608) of Hook Norton, illegitimate brother of Queen Elizabeth's champion, Sir Henry Lee.
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He followed Day, the Bishop of Chichester, in persuading Sir James Hales to abjure Protestantism in 1554.