The following episode featured a skit parodying the debate between Palin and Joe Biden (played by Jason Sudeikis).
Some of her recurring sketches include a parody of Fox & Friends, which she does with Taran Killam and Bobby Moynihan, as well as The Miley Cyrus Show, which she does with Jason Sudeikis and the show's host.
Jason Mraz | Jason Alexander | David Jason | Jason Robards | Jason Grimshaw | Jason Kidd | Jason Kenney | Jason Isaacs | Jason Statham | Jason Newsted | Jason | Jason Priestley | Jason Aldean | Jason Scott Lee | Jason Schwartzman | Jason Mewes | Jason Ritter | Jason Donovan | Jason Bourne | Jason Aaron | Jason Williams | Jason Reeves | Jason McCoy | Jason McAteer | Jason Derulo | Jason Blaine | Jason Biggs | Freddy vs. Jason | Jason Williams (basketball, born 1975) | Jason Voorhees |
Mooney, along with John Milhiser, Michael Patrick O'Brien, Noël Wells, Brooks Wheelan, and his comedy partner and friend, Beck Bennett, joined the thirty-ninth season of Saturday Night Live to fill the void left by the recent departures of Fred Armisen, Bill Hader, and Jason Sudeikis.
In 2008, she wrapped the independent film TiMER with Emma Caulfield and Desmond Harrington, and appeared in the Endgame Productions' comedy film, A Good Old Fashioned Orgy with Leslie Bibb, Lake Bell, and Jason Sudeikis.