After a month spent crossing the desert into the Ethiopian highlands, the party reached Fremona, where Lobo assumed the responsibilities of superintendent of the missions in Tigray.
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He entered into a correspondence with Henry Oldenburg of the Royal Society concerning the source of the Nile, which likely led to the publication in London of a little book entitled A Short Relation of the River Nile, of its source and current; of its overflowing the campagnia of Ægypt, till it runs into the Mediterranean and of other curiosities: written by an eye-witnesse, who lived many years in the chief kingdoms of the Abyssine Empire.
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Gabriel Pereira reported in 1903 that he had found three short works in manuscript by Lobo in the library of the Duke of Palmela, and in 1966 Fr.
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Due largely to the behaviour of the Portuguese Jesuit Afonso Mendes, whom Pope Urban VIII appointed as Patriarch of Ethiopia in 1622, Emperor Fasilides expelled the Patriarch and the European missionaries, who included Jerónimo Lobo, from the country in 1636; these contacts, which had seemed destined for success under the previous Emperor, led instead to the complete closure of Ethiopia to further contact with Rome.