The railway line from Oschersleben to Jerxheim in Lower Saxony was closed in 1992.
To the west it connected with the Wolfenbüttel–Helmstedt line at Jerxheim.
The section from Wolfenbüttel to Jerxheim was opened in 1843 and was one of the oldest railways in Germany and part of the main line between Berlin and western Germany until the opening of the Berlin–Lehrte railway in 1871.
All railways between Helmstedt (Brunswick–Magdeburg railway) and Walkenried (South Harz Railway) were disrupted at the Inner-German border, including the Jerxheim crossing on the line from Magdeburg via Eilsleben and Oschersleben.
In 1843 the Wolfenbüttel–Jerxheim–Oschersleben line was opened, which together with the Magdeburg–Halberstadt line formed a connection with Berlin.
On 10 July 1843 a line was opened by the Duchy of Brunswick State Railway from Wolfenbüttel to the Magdeburg–Halberstadt line at Oschersleben via Schöppenstedt, Jerxheim and Gunsleben.