The by-election was triggered by the resignation on 21 December 2010 of John Brumby, the former Premier of Victoria whose 11-year incumbent Labor government was defeated at the 2010 election.
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She questioned whether the Victorian Chief Scientist, Sir Gustav Nossal, was independent enough to advise the Government of Victoria on the subject, and has been critical of Victorian Premier John Brumby for approving genetically modified canola plantations in Victoria.