He also appeared in a starring roles in the 1976-1977 TV miniseries Once an Eagle and the short-lived 1977 TV series, "Big Hawaii," in which he played Mitch Fears, the rebellious son of rich landowner Barret Fears (John Dehner).
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Clarke, a slightly overweight actor with a double chin, specialized in playing avuncular, rather timid characters, with one of his largest parts being frightened gambler "Foursquare Farley" in the Maverick episode "Greenbacks, Unlimited" opposite James Garner and John Dehner.
After Man Without a Gun, Rex Reason was again cast as a reporter, Scott Norris, on ABC's crime drama, The Roaring Twenties, with co-stars Dorothy Provine (who had guest-starred on Man Without a Gun), John Dehner, Donald May, Mike Road, and Gary Vinson.