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An hereditary member of the House of Bourbon through Charles I, Duke of Bourbon and Agnes of Burgundy, Charles II, being a younger son, was appointed Canon of Lyon in 1443 and soon after, in June 6, 1444, elected Archbishop of Lyon at the age of 11, following the death of Amedée de Talaru and the renunciation of John III of Bourbon, illegitimate offspring of his grandfather John I, Duke of Bourbon.