The theoretical advances and greatly improved data available by the 1970s enabled a "grand synthesis" to be made, best known from the 1976 paper Variations in the earth’s orbit: pacemaker of the ice ages (in Science), by J.D. Hays, Shackleton and John Imbrie, which is still very widely accepted today, and covers the MIS timescale and the causal effect of the orbital theory.
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