When McHugh became head of Johns Hopkins psychiatry department in 1975, he fought John Money and other founders of the school's pioneering Gender Identity Clinic to have it successfully shut down.
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In a study that was performed on girls who were more “masculinized” than others, biological determinists John Money and Anke Ehrhardt looked for ways to describe femininity that fit into the common definition of it, such as clothing preference, using makeup, etc.
He conducted and published many interviews with such leading figures in the discourse as Judd Marmor, Richard Pillard, Thomas Szasz, John Money, Charles Silverstein, Masters and Johnson, Richard Green, Mary Calderone, John Boswell, John D'Emilio and Estelle Freedman, and Martin Duberman.