The children that lived to adulthood were as follows: John Crowley who married Theodosia Gascoigne; Mary who married Sir James Hallett; Lettice married Sir John Hynde Cotton, 3rd Baronet; Sarah married Humphry Parsons; Anna married Richard Fleming; and Elizabeth to Lord St John of Bletsoe.
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St John was born at Woodford, Northamptonshire, the son of John St John, 12th Baron St John of Bletso and his wife Susanna Louisa Simond, daughter of Peter Simond.
Howard married Ann St John, daughter of John St John, 2nd Baron St John of Bletso, on 7 February 1597: they had one daughter, Elizabeth (1603–1671), who married John Mordaunt, 1st Earl of Peterborough.