The combination of symptoms was first reported in 1964 by R.H. Winterbauer, at that point a medical student at Johns Hopkins School of Medicine.
In an interview with the Washington Post, gastroenterologist Theodore Bayless of Johns Hopkins School of Medicine suggested that such a course can relieve symptoms of lactose intolerance, but the relief would not be permanent, particularly if the user were to take antibiotics at a later date.
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The journal was established in 1896 at the Johns Hopkins School of Medicine by William H. Welch, the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute (since renamed Rockefeller University).
He completed his pre-medical studies at Tulane University where he pledged Kappa Alpha Psi, and went on to graduate first in his class from Johns Hopkins School of Medicine.
The OPM tools have been successfully used for developing several public molecular biology databases, such as the Genome database at the Johns Hopkins School of Medicine in Baltimore, and the German Genome Resource Center's Primary Database in Berlin, and for setting up prototype molecular biology multi-database systems.