The combination of symptoms was first reported in 1964 by R.H. Winterbauer, at that point a medical student at Johns Hopkins School of Medicine.
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The initialism "CREST" refers to the five main features: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia.
Auguste Gabriel Maurice Raynaud (1834–1881), is the French doctor who discovered Raynaud's Disease, a rare vasospastic disorder which contracts blood vessels in extremities and is the "R" in the CREST syndrome acronym, in the late 19th century.
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Sclerodactyly is a component of the CREST variant of scleroderma (CREST is an acronym that stands for calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.)