At 41 years old, Simons was recruited by the Georgia governor Roy Barnes and the Robert W. Woodruff Foundation of Atlanta to be the Founding Director of the Winship Cancer Institute at Emory University.
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Simons completed his residency in internal medicine at Massachusetts General Hospital and a clinical fellowship in medical oncology at the Johns Hopkins Oncology Center.
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Before entering medical school, Simons studied as a Rotary International Postgraduate Fellow in the Humanities at the University of Kent in Canterbury, England, and a Nuffield Foundation Fellow in the Department of Biochemistry at the University of Cambridge.
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