Keith Mann writes that the nature of police interest in animal rights activists was such that working alone was safer, and Horne was anyway a reserved man, happy to go out alone and "do stuff," as he put it.
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Together with Keith Mann and Danny Attwood, Horne was part of a small Animal Liberation Front cell that raided Harlan Interfauna, a British company in Cambridge that supplies laboratory animals and organs, on 17 March 1990, Horne's 38th birthday.
Viewed as a cause célèbre within the global animal rights movement, he has acted as a spokesman for the ALF, attracting the support of celebrities such as Carla Lane and Celia Hammond.
He also directed Angels of Mercy? (2006), a Channel 4 documentary about Keith Mann and the Animal Liberation Front, and Almost Adult (2006), about two teenage girls who emigrate from the Congo and Kenya to the UK.
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Keith Mann stood in Oxford West and Abingdon against the Liberal Democrat MP Evan Harris; the area has been the focus of protests against the building of Oxford University's Biomedical Sciences Building.