In January 1497 he landed at Modon and later captured several Venetian ships at the Ionian Sea and transported them, along with their cargo, to Euboea.
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With the Battle of Modon, the Ottoman fleet and army quickly overwhelmed most of the Venetian possessions in Greece.
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In July 1501 Kemal Reis, accompanied by his nephew Piri Reis, set sail from the port of Modon with a force of 3 galleys and 16 fustas and went to the Tyrrhenian Sea, where he took advantage of the war between Jacopo d'Appiano, ruler of Piombino, and the Papal forces under the command of Cesare Borgia.
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From there Kemal Reis set sail and bombarded the Venetian ports on the island of Corfu, and in August 1500 he once again defeated the Venetian fleet at the Battle of Modon which is also known as the Second Battle of Lepanto.
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Still in May 1505 Kemal Reis captured the Island of Lemnos and assaulted the Island of Chios, before returning to Modon in July 1505.
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