In protest to the canalization of the river and its resultant damage to the habitat, Florida author Piers Anthony based the plot of the tenth Xanth novel, Vale of the Vole, around the straightening of the "Kiss-Mee River," an obvious parody to "Kissimmee."
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Below Lake Kissimmee, the river forms the boundary between Osceola County and Polk County, between Highlands County and Okeechobee County, and between Glades County and Okeechobee County before it flows into Lake Okeechobee.
The novel was written as a satirical jab at the canalization of the Kissimmee River in Piers' native state of Florida as a result of the effects of the 1947 Atlantic hurricane season.
Mississippi River | River Thames | Amazon River | Columbia River | Hudson River | Colorado River | Potomac River | river | Ohio River | Missouri River | Delaware River | Murray River | River Tyne | Madeira River | Volga River | River Nene | River Clyde | River Trent | River Severn | Amur River | River Wear | Allegheny River | Red River | Dnieper River | Yarra River | Paraná River | River Tees | Fraser River | Yangtze River | Tocantins River |
Belle Glade culture, an archaeological culture in the Lake Okeechobee basin and Kissimmee River Valley
Lake Istokpoga, the largest lake in the county is connected to the Kissimmee River by two canals; the Istokpoga canal, and the C41 (outflow) canal.