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The episode introduced the recurring characters of The Lone Gunmen, played by Bruce Harwood, Dean Haglund and Tom Braidwood; and saw Jerry Hardin reprise his role as Deep Throat.
Scully's mother, Margaret, (Sheila Larken) tells Mulder a story about Dana shooting a snake with her brothers as a child and regretting what she did afterwards.
In season 3 finale (Talitha Cumi), Mulder gets a call from AD Skinner, who tells him that his mother has been admitted to a hospital in Quonochontaug.
Jeremiah Smith takes Mulder to a covert bee husbandry facility in remote Alberta.
Chuck Burks (Bill Dow), a digital photo expert, uses software to uncover evidence of electromagnetic disturbances in the shape of a child, holding the balloon.
Soon afterwards, Deep Throat (Jerry Hardin) approaches Fox Mulder with Secare's case, saying he is of major importance to revealing the truth.
This spell has been used by Xia Tian (夏天), Xiu (脩), Xia Yu (夏宇), Han (寒), Lan Ling Wang (蘭陵王), Jiu Wu (灸舞) and the rest of Dong Cheng Wei.
Ultra-rare cards included photo variants of Agents Fox Mulder, Dana Scully, Alex Krycek and Assistant Director Walter Skinner, as well as cards for Deep Throat, X, the Lone Gunmen, and pivotal events in the first two seasons.
Several of the actors from the TV series reprise their roles in the game, including David Duchovny (Mulder), Gillian Anderson (Scully), Mitch Pileggi (Skinner), Steven Williams (X) and - very briefly and depending upon the outcome of the game, William B. Davis (The Smoking Man).