Syracuse, which led an alliance including Locris, Gela, and other cities, regained the initiative by 425 BC, recaptured Messina, and threatened several of Athens' allies.
In 210 BC, Hannibal again proved his superiority in tactics by inflicting a severe defeat at Herdoniac (modern Ordona) in Apulia upon a proconsular army, and in 208 BC destroyed a Roman force engaged in the siege of Locri Epizephyri.
Hanno received the reinforcements landed by Bomilcar, the leading Carthaginian admiral, consisting of 4,000 cavalry and 40 elephants, near Locri and joined Hannibal near Nola later that year.
Ampelographers believe that this was the earliest mention of Mantonico bianco and that the grape is likely native to the Locri region in Reggio Calabria.
Ballaios' coins were in circulation in the regions along both Adriatic coasts; along the eastern Adriatic, they have been found in a broad area extending from Phoenice in Epirus to Shkodër, in present day Albania, to Pharos, and along the western Adriatic from Leuca and Locri to Aquileia, indicating trade activity of Ballaios that was no longer controlled by Issa.
In 282 BC, after a battle against the Samnites, Lucanians, Bruttians and Thurii, Roman troops entered the Italian Greek colonies of Croton, Lokroi, and Rhegium.
James M. Redfield, professor of Classics at the University of Chicago, in his book The Locrian Maidens: Love and Death in Greek Italy, states that the Locrians of Epizephyrian Locri had a special way to treat the sex difference.
The cities and towns of the Locri Epicnemidii, along the coast from north to south, were: Alpenus, Nicaea, Scarphe (Scarpheia), Thronium, Cnemis (Cnemides), more inland, Tarphe later Pharygae, and Augeiae.