From the US side, Los Algodones is most easily reached via Interstate 8 and south a short distance (3.33 Km / 2.07 mi) along State Route 186/Andrade Road to the international border at Andrade, California.
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The warm, dry climate of the area attracts a number of older tourists from across the United States and Canada who settle during the winter in the nearby towns of Yuma, Arizona and Winterhaven, California.
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The Port of Entry at East Calexico, California is one of the three ports of entry in the Imperial Valley, with the other ports of entry in Calexico (Mexicali downtown) 10 km west and the other 60 km east at Andrade, California (Los Algodones, Baja California).