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Charles IV, Duke of Anjou, also Charles of Maine, Count of Le Maine and Guise (1446–1481) was the son of the Angevin prince Charles of Le Maine, Count of Maine, who was the youngest son of Louis II of Anjou and Yolande of Aragon, Queen of Four Kingdoms.
He and his army occupied Avignon in 1398 and started a five year siege of the Palais des Papes where the Avignon Pope Benedict XIII was, which ended when Benedict managed to escape from Avignon on 12 March 1403 and find shelter in territory belonging to Louis II of Anjou.