In 1836, George spotted lands in Iowa which reminded him of his boyhood home in Virginia, staking a claim to what he dubbed "Virginia Grove" in Louisa County.
Prior to colonial settlement, the area comprising Louisa County was occupied by several indigenous peoples including the Tutelo, the Monacan, and the Manahoac peoples, who eventually fled to join the Cayuga Iroquois (Haudenosaunee) people in New York state under pressure from English settlers.
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Lipscomb was born to Granville Lipscomb (born January 13, 1802 in Louisa County, Virginia, died November 16, 1853) and his second wife Ann E. Lipscomb (born January 25, 1799 in Louisa County, Virginia, died January 29, 1835 in Illinois) (called "Nancy" in some sources.) Granville had previously been married, on December 14, 1825 in Spotsylvania, Virginia, to the former Ellen Guerner.
After the war, McComb lived in Alabama and Mississippi, eventually settling in Gordonsville, Louisa County, Virginia, where he was a farmer for nearly fifty years.