The lower Luangwa Valley is crossed by just one road, the Great East Road at the Luangwa Bridge, about 10 km south of the Luangwa-Lunsemfwa confluence.
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The principal settlement in the Middle and Upper Luangwa Valley is Mfuwe which serves the tourism industry and has an international airport.
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It is somewhat broken north of Lake Kariba, but is particularly steep and well-formed from a point north of Siavonga going east through the Lower Zambezi National Park to the Luangwa River.
Chama is connected with Lusaka by a different road which follows the Luangwa River and passes Petauke and Nyimba, connecting to the Great East Road.