The river leaves Lake Tanganyika at Kalemie and flows through a gap in the highlands westward through the Tanganyika District to join the Lualaba between Kabalo and Kongolo.
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Around 1800, in the second half of the rule of the Luba Emperor Ilunga Sungu, Luba forces launched raids over the Lualaba that at one point reached as far as Kalemie.
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At the time of the eastward expansion of the Luba Kingdom under King Ilunga Sungu around 1800, Hemba people were living in a territory bounded by the Lukuga River in the north, the Luvua River in the south and the Lualaba River to the west.