This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo).
There is a mitochondrial outer membrane fusion machinery, composed by proteins of the Fzo1 family in yeast or by MFN1, MFN2 in mammals, and a mitochondrial inner membrane fusion machinery, with the Mgm1 protein in yeast or the equivalent OPA1 in mammals.
MFN1 |