The drama centers around the encounter of the eponymous Madeinusa (Magaly Solier), a teenaged girl selected as the festival's Mater Dolorosa and daughter of the village mayor, with Salvador.
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The villagers of Manayaycuna believe that during "Holy Time" God, symbolized by an effigy of Christ, is dead and, therefore, nothing is a sin.
Madeinusa, a 2005 film about a village that believes it is impossible to sin from Good Friday to Easter.