In contravention of Cosa Nostra rules on the killing of a family boss, the plotters did not ask permission to kill D'Amato from the Mafia Commission in New York.
At the end of the 1950s, Profaci received the first challenge to his authority from capo Joe Gallo and his brothers Larry and Albert, perhaps with encouragement from Gambino crime family boss Carlo Gambino, Profaci's main rival on the Mafia Commission.
On November 18, 1986, Scopo was convicted in the Commission Trial of racketeering for carrying out the orders of the Mafia Commission.
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In 1980, the FBI initiated Operation Genus against all five of the New York Cosa Nostra families, an effort that would result in the infamous Mafia Commission trial.
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At this time, mob associate and Florida gambling operator Meyer Lansky persuaded the Mafia Commission that both Miami and Miami Beach should be considered "open cities", places in which any crime family in the country could set up operation.
The operation foiled an attempt to reconstitute a new Mafia Commission after the arrests of Mafia bosses Bernardo Provenzano, Antonio Rotolo and Salvatore Lo Piccolo in 2006 and 2007.