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Because SMTP Proxies can be implemented using lighter-weight programming techniques such as asynchronous IO (for example nginx, Node.js, Netty and Libevent), thousands of connections can be juggled using the same resources as a much smaller number of connections in the context of a full-blown store and forward email server.
Mercury is a fully independent mail server and can provide email services to all standards-compliant email clients, such as Eudora or Microsoft Outlook.
Mirapoint Email Appliance is a Unix-like standards-compliant black-box e-mail server, with built-in anti-spam, anti-virus, webmail, POP, IMAP, calendar, and LDAP routing options available.